Tapentadol Aspadol 100mg

Tapentadol, also known by the brand name Aspadol in some regions, is an opioid analgesic used for managing moderate to severe pain. Its unique dual mechanism of action, involving opioid receptor agonism and norepinephrine reuptake inhibition, distinguishes it. This allows it to effectively alter the body’s perception of pain, providing comprehensive relief for various conditions including injuries, surgeries, or chronic pain like osteoarthritis.

Uses

• Manages moderate to severe pain, including that from injuries, surgeries, or chronic conditions like osteoarthritis.
• Applicable for both acute (e.g., post-surgical) and chronic pain.

How It Works: Acts via two mechanisms: binding to opioid receptors in the brain/spinal cord for pain alleviation, and inhibiting norepinephrine reuptake, enhancing its analgesic effects.

Dosage & Administration

• Available in immediate-release (short-term) and extended-release (chronic pain) forms.
• Immediate-Release: Typically 50-100 mg every 4-6 hours (max ~600 mg/day).
• Extended-Release: Starts at 50-100 mg twice daily (max 500 mg twice daily).
• Taken orally with or without food; extended-release tablets must be swallowed whole.

Side Effects

• Common: Nausea, vomiting, drowsiness, dizziness, constipation, headache.
• Serious: Respiratory depression (slowed breathing), dependence/addiction risk, severe allergic reactions. Seek immediate medical attention for serious effects.

Warnings & Precautions

• High Risk: Potential for physical dependence, addiction, and misuse.
• Interactions: Avoid alcohol/other CNS depressants (increased respiratory risk). Interacts with antidepressants, liver enzyme-affecting medications.
• Medical Conditions: Use cautiously with respiratory issues, liver/kidney disease, GI problems, or substance abuse history.
• Pregnancy/Breastfeeding: Use only if clearly needed; can pass into breast milk.
• Considerations: Long-term use leads to tolerance; use for shortest necessary duration under supervision. Store securely. Follow prescriptions strictly.