Modanil is a prescription medication primarily used to treat various sleep disorders, including narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder. Known for its wakefulness-promoting properties, it helps individuals combat excessive daytime sleepiness and maintain alertness. It is occasionally used off-label for other purposes.
Uses:
- Manages excessive daytime sleepiness in narcolepsy.
- Reduces daytime sleepiness for individuals with Obstructive Sleep Apnea (OSA) (as adjunct to CPAP).
- Improves alertness during waking hours for those with Shift Work Sleep Disorder.
How It Works:
As a wakefulness-promoting agent, its exact mechanism is not fully understood, but it’s believed to affect brain neurotransmitters like dopamine, norepinephrine, and serotonin, which regulate wakefulness.
Dosage & Administration:
- Typically available in tablet form.
- Usual dose for narcolepsy/OSA: 200 mg once daily in the morning.
- For shift work: 200 mg about 1 hour before work shift.
- Taken orally with or without food.
Side Effects:
- Common: Headache, nausea, nervousness, anxiety, insomnia (if taken late).
- Serious: Severe skin reactions (e.g., Stevens-Johnson syndrome), increased blood pressure/heart rate, psychiatric symptoms (hallucinations, mania, aggression).
Warnings & Precautions:
- Drug Interactions: Can interact with antidepressants, anticonvulsants, oral contraceptives (may reduce efficacy).
- Medical Conditions: Use cautiously with heart disease, high blood pressure, liver/kidney problems, or psychiatric disorders.
- Pregnancy: Use only if clearly needed, as effects on fetus are not well-studied.
- Considerations: Lower abuse potential than amphetamines, but misuse is possible. Long-term use may lead to tolerance.
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