Gabapentin is a prescription medication, classified as an anticonvulsant or antiepileptic, widely used to treat various conditions including nerve pain, seizures, and certain anxiety disorders. It modulates nerve activity in the brain, making it effective for conditions like diabetic neuropathy, postherpetic neuralgia, partial seizures, and restless legs syndrome.
Uses:
- Treats neuropathic pain (e.g., diabetic neuropathy, postherpetic neuralgia).
- Used as adjunctive therapy for partial seizures.
- Alleviates discomfort from Restless Legs Syndrome (RLS).
- Off-label uses include anxiety, fibromyalgia, chronic pain.
How It Works:
Affects how nerves transmit signals, binding to calcium channels to reduce excitatory neurotransmitter release and calm overactive nerve activity.
Dosage & Administration:
- Taken orally (capsules, tablets, oral solution), typically 2-3 times a day with or without food.
- Dosage is individualized based on condition, history, and response.
- Adjustments needed for kidney impairment.
Side Effects:
- Common: Dizziness, drowsiness, fatigue, swelling, nausea/vomiting, coordination problems, double vision, weight gain.
- Serious: Severe allergic reactions, mood changes, suicidal thoughts, breathing difficulties (especially with other CNS depressants).
Warnings & Precautions:
- Suicidal Thoughts: Monitor closely for mood changes.
- Withdrawal: Discontinue gradually to avoid seizures.
- Kidney Function: Lower dose or adjusted schedule for kidney problems.
- Safety: Avoid driving/operating machinery due to dizziness/drowsiness.
- Pregnancy/Breastfeeding: Use only if benefits outweigh risks; not recommended during breastfeeding.
- Considerations: Elderly patients may be more sensitive. Limit alcohol. Interactions with antacids, opiates, mood stabilizers.
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